Which factor is a risk for developing peripheral neuropathy?

Diabetes is recognized as a significant risk factor for developing peripheral neuropathy. This condition arises when high levels of glucose in the blood damage the peripheral nerves over time. Chronic hyperglycemia affects the nerve fibers through various mechanisms, including the production of sorbitol and fructose in nerve tissues, which can lead to nerve damage and decreased function, ultimately resulting in symptoms such as pain, tingling, or numbness, especially in the extremities.

Furthermore, diabetes can lead to other complications that exacerbate peripheral neuropathy, including poor circulation and increased susceptibility to infections or injuries. As such, individuals with diabetes are at a heightened risk for this condition compared to those with other factors like high blood pressure, thyroid disorders, or obesity, which, while they may influence overall health, do not directly cause peripheral nerve damage in the same way that prolonged high blood sugar levels do.